PD-L1/HDAC6-IN-1, CAS [[2834094-36-7]] Preis auf Anfrage

Produktübersicht

• Artikelname: PD-L1/HDAC6-IN-1, CAS [[2834094-36-7]] Preis auf Anfrage
• Artikelnummer: TGM-T205403
• Hersteller Artikelnummer: T205403
• Alternativnummer: TGM-T205403-10MG,TGM-T205403-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

PD-L1/HDAC6-IN-1 (Compound HP29) is an inhibitor targeting both PD-L1 and HDAC6, effectively disrupting the PD-L1/PD-1 interaction and inhibiting HDAC6 activity, with IC50 values of 26.8 nM and 69 nM, respectively. This compound enhances the cytotoxicity of Jurkat T cells against HepG2 cells, exhibiting an IC50 of 3.4 µM. In rats, PD-L1/HDAC6-IN-1 demonstrates favorable pharmacokinetics, showing a drug exposure level of 871.62 ngh/mL, and displays antitumor activity in a B16-F10 xenograft mouse model.

Produkteigenschaften

• Molekulargewicht: 447.569
• CAS Nummer: [2834094-36-7]
• Formel: C27H33N3O3
• Target-Kategorie: HDAC|||PD-1/PD-L1

Bilder

T205403