PD-L1/HDAC6-IN-1, CAS [[2834094-36-7]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T205403
Supplier Catalog Number:
T205403
Alternative Catalog Number:
TGM-T205403-10MG,TGM-T205403-50MG
Manufacturer:
TargetMol
Category:
Biochemikalien
PD-L1/HDAC6-IN-1 (Compound HP29) is an inhibitor targeting both PD-L1 and HDAC6, effectively disrupting the PD-L1/PD-1 interaction and inhibiting HDAC6 activity, with IC50 values of 26.8 nM and 69 nM, respectively. This compound enhances the cytotoxicity of Jurkat T cells against HepG2 cells, exhibiting an IC50 of 3.4 µM. In rats, PD-L1/HDAC6-IN-1 demonstrates favorable pharmacokinetics, showing a drug exposure level of 871.62 ngh/mL, and displays antitumor activity in a B16-F10 xenograft mouse model.
Molecular Weight:
447.569
CAS Number:
[2834094-36-7]
Formula:
C27H33N3O3
Target:
HDAC|||PD-1/PD-L1
T205403
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