PROTAC CDK9 degrader-11, CAS [[3039540-19-4]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC CDK9 degrader-11, CAS [[3039540-19-4]] Preis auf Anfrage
• Artikelnummer: TGM-T205652
• Hersteller Artikelnummer: T205652
• Alternativnummer: TGM-T205652-10MG, TGM-T205652-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3, Black: linker, Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)

Produkteigenschaften

• Molekulargewicht: 807.768
• CAS Nummer: [3039540-19-4]
• Formel: C39H48Cl2N10O5
• Target-Kategorie: CDK|||PROTACs

Bilder

T205652