PROTAC CDK9 degrader-11, CAS [[3039540-19-4]] Preis auf Anfrage

Product Overview

• Article Name: PROTAC CDK9 degrader-11, CAS [[3039540-19-4]] Preis auf Anfrage
• Biozol Catalog Number: TGM-T205652
• Supplier Catalog Number: T205652
• Alternative Catalog Number: TGM-T205652-10MG, TGM-T205652-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3, Black: linker, Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)

Product Properties

• Molecular Weight: 807.768
• CAS Number: [3039540-19-4]
• Formula: C39H48Cl2N10O5
• Target: CDK|||PROTACs

Images

T205652