(Iso)-TRPV4 antagonist 5 are potent, selective, and orally active transient receptor potential vanilloid 4 (TRPV4) channel blockers for the treatment of pulmonary edema and respiratory diseases. This compound was discovered through optimization of a spirocarbamate lead designed to reduce interstitial lung fluid. Research on its derivatives and related compounds primarily focuses on improving metabolic stability, reducing lipophilicity to enhance clearance, and increasing potency.
Molekulargewicht:
478.52
Reinheit:
99.63%
CAS Nummer:
[3026084-13-6]
Formel:
C25H27FN6O3
Target-Kategorie:
TRP/TRPV Channel
T205925L
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