(Iso)-TRPV4 antagonist 5 are potent, selective, and orally active transient receptor potential vanilloid 4 (TRPV4) channel blockers for the treatment of pulmonary edema and respiratory diseases. This compound was discovered through optimization of a spirocarbamate lead designed to reduce interstitial lung fluid. Research on its derivatives and related compounds primarily focuses on improving metabolic stability, reducing lipophilicity to enhance clearance, and increasing potency.
Molecular Weight:
478.52
Purity:
99.63%
CAS Number:
[3026084-13-6]
Formula:
C25H27FN6O3
Target:
TRP/TRPV Channel
T205925L
* VAT and and shipping costs not included. Errors and price changes excepted
