VU0467319 (Compound VU319) is a highly selective positive allosteric modulator of the M1 receptor, capable of crossing the blood-brain barrier and orally active, with an EC50 of 492 nM. It demonstrates selectivity in humans and rats (EC50 > 30 µM) compared to M2-5 receptors. This compound improves cognitive deficits associated with Alzheimers disease (AD) through central M1 muscarinic receptor activation and does not induce cholinergic adverse effects, highlighting its potential in AD research.
Molekulargewicht:
390.385
CAS Nummer:
[1432438-14-6]
Formel:
C22H16F2N4O
Target-Kategorie:
AChR
T206889
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
