VU0467319 (Compound VU319) is a highly selective positive allosteric modulator of the M1 receptor, capable of crossing the blood-brain barrier and orally active, with an EC50 of 492 nM. It demonstrates selectivity in humans and rats (EC50 > 30 µM) compared to M2-5 receptors. This compound improves cognitive deficits associated with Alzheimers disease (AD) through central M1 muscarinic receptor activation and does not induce cholinergic adverse effects, highlighting its potential in AD research.
Molecular Weight:
390.385
CAS Number:
[1432438-14-6]
Formula:
C22H16F2N4O
Target:
AChR
T206889
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