RTx-152 is an allosteric Poltheta-pol inhibitor (IC50: 6.2 nM) that targets Poltheta captured on DNA. It selectively kills cancer cells with homologous recombination (HR) defects and inhibits resistance to PARP inhibitors across various genetic backgrounds, including HR-proficient cells. Additionally, RTx-152 selectively eliminates BRCA2-deficient cells.
Molekulargewicht:
479.35
CAS Nummer:
[3035072-48-8]
Formel:
C20H16F7N3O3
Target-Kategorie:
DNA/RNA Synthesis
T209740
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten