RTx-152 is an allosteric Poltheta-pol inhibitor (IC50: 6.2 nM) that targets Poltheta captured on DNA. It selectively kills cancer cells with homologous recombination (HR) defects and inhibits resistance to PARP inhibitors across various genetic backgrounds, including HR-proficient cells. Additionally, RTx-152 selectively eliminates BRCA2-deficient cells.
Molecular Weight:
479.35
CAS Number:
[3035072-48-8]
Formula:
C20H16F7N3O3
Target:
DNA/RNA Synthesis
T209740
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