PROTAC SOS1 degrader-10, CAS [[3043923-74-3]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC SOS1 degrader-10, CAS [[3043923-74-3]] Preis auf Anfrage
• Artikelnummer: TGM-T210119
• Hersteller Artikelnummer: T210119
• Alternativnummer: TGM-T210119-10MG,TGM-T210119-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

PROTACSOS1 degrader-10 (Compound 11o) is a degrader of son of sevenless 1 (SOS1) that functions through CRBN- and protease-dependent mechanisms. It effectively degrades SOS1 in KRAS-mutated cancer cells SW620, A549, and DLD-1, with DC50 values of 2.23, 1.85, and 7.53 nM, respectively. Additionally, PROTACSOS1 degrader-10 inhibits the proliferation of SW620, A549, and DLD-1 cells, with IC50 values of 36.7, 52.2, and 107 nM, and suppresses ERK phosphorylation.

Produkteigenschaften

• Molekulargewicht: 969.1
• CAS Nummer: [3043923-74-3]
• Formel: C51H63F3N10O6
• Target-Kategorie: PROTACs|||Ras

Bilder

T210119