LRK-4189 is an orally active, selective PIP4K2C PROTAC degrader with a DC50 <500 nM in MOLT-4 cells. It induces endogenous apoptosis and activates the interferon signaling pathway, exhibiting antitumor activity against microsatellite stable (MSS) colorectal cancer (CRC) cells.
Molekulargewicht:
793.9
CAS Nummer:
[3063346-83-5]
Formel:
C43H49F2N9O4
Target-Kategorie:
PROTACs
T210497
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