FGFR2/3-IN-3, CAS [[3069945-78-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: FGFR2/3-IN-3, CAS [[3069945-78-1]] Preis auf Anfrage
• Artikelnummer: TGM-T210986
• Hersteller Artikelnummer: T210986
• Alternativnummer: TGM-T210986-10MG,TGM-T210986-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

FGFR2/3-IN-3 is a dual-target FGFR2/3 inhibitor with IC50 values of 2.7 nM (TEL-FGFR2) and 3.9 nM (TEL-FGFR3), displaying efficacy against both wild-type and mutant FGFR3. It exhibits low CYP3A4 inhibition and minimal hERG toxicity. By inhibiting mutant FGFR3-mediated pathways, FGFR2/3-IN-3 improves chondrocyte proliferation and differentiation imbalances, promoting bone growth. In a dwarfism mouse model, it demonstrates growth-promoting effects, indicating potential for treating bone development disorders such as achondroplasia (ACH).

Produkteigenschaften

• Molekulargewicht: 569.46
• CAS Nummer: [3069945-78-1]
• Formel: C28H27Cl2FN6O2
• Target-Kategorie: FGFR|||Cytochromes P450

Bilder

T210986