PNU-183792 is a 4-oxo-1,4-dihydroquinoline that acts as an orally active inhibitor of herpesvirus polymerases (HSV polymerases). It exhibits broad-spectrum antiviral activity, with IC50 values of 0.69 µM for human cytomegalovirus (HCM), 0.37 µM for varicella-zoster virus, and 0.58 µM for herpes simplex virus (HSV) polymerase. PNU-183792 shows no activity against human alpha, gamma, and delta polymerases but inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV), and rat cytomegalovirus (RCMV).
Molekulargewicht:
425.91
CAS Nummer:
[282536-25-8]
Formel:
C23H24ClN3O3
Target-Kategorie:
HSV
T211119
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
