USP7-IN-18, CAS [[3052223-40-9]] Preis auf Anfrage

Produktübersicht

• Artikelname: USP7-IN-18, CAS [[3052223-40-9]] Preis auf Anfrage
• Artikelnummer: TGM-T211314
• Hersteller Artikelnummer: T211314
• Alternativnummer: TGM-T211314-10MG,TGM-T211314-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

USP7-IN-18 (Compound X21) serves as a novel USP7 inhibitor by directly suppressing enzyme activity and modulating downstream pathways, including the newly identified PCLAF target. At concentrations of 0.25-1 µM for 24 hours, it exhibits inhibitory effects. USP7-IN-18 effectively reduces proliferation in leukemia (RS4,11) and colon cancer (MC38/CT26.WT) cells at 0.01-100 µM over 72 hours. It demonstrates high selectivity for USP7 at 2.5 µM within 0.5 hours, surpassing eight other deubiquitinating enzymes. SPR analysis shows that at 1.95-2000 nM for 3 minutes, the compound binds the catalytic domain of USP7 with a KD value of 4.9 µM.

Produkteigenschaften

• Molekulargewicht: 546.08
• CAS Nummer: [3052223-40-9]
• Formel: C30H28ClN3O3S
• Target-Kategorie: MDM-2/p53|||DNA Methyltransferase|||DUB

Bilder

T211314