USP7-IN-18, CAS [[3052223-40-9]] Preis auf Anfrage

Product Overview

• Article Name: USP7-IN-18, CAS [[3052223-40-9]] Preis auf Anfrage
• Biozol Catalog Number: TGM-T211314
• Supplier Catalog Number: T211314
• Alternative Catalog Number: TGM-T211314-10MG,TGM-T211314-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

USP7-IN-18 (Compound X21) serves as a novel USP7 inhibitor by directly suppressing enzyme activity and modulating downstream pathways, including the newly identified PCLAF target. At concentrations of 0.25-1 µM for 24 hours, it exhibits inhibitory effects. USP7-IN-18 effectively reduces proliferation in leukemia (RS4,11) and colon cancer (MC38/CT26.WT) cells at 0.01-100 µM over 72 hours. It demonstrates high selectivity for USP7 at 2.5 µM within 0.5 hours, surpassing eight other deubiquitinating enzymes. SPR analysis shows that at 1.95-2000 nM for 3 minutes, the compound binds the catalytic domain of USP7 with a KD value of 4.9 µM.

Product Properties

• Molecular Weight: 546.08
• CAS Number: [3052223-40-9]
• Formula: C30H28ClN3O3S
• Target: MDM-2/p53|||DNA Methyltransferase|||DUB

Images

T211314