ST171 is a dual-action 5-HT1AR agonist with a Ki of 0.41 nM. It selectively activates the Gi/o signaling pathway and inhibits cAMP accumulation mediated by 5-HT1AR, without Gs activation and with minimal beta-arrestin recruitment. ST171 reduces hypersensitivity in mouse models of chronic neuropathic and inflammatory pain and is applicable for pain research.
Target-Kategorie:
5-HT Receptor
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