ST171 is a dual-action 5-HT1AR agonist with a Ki of 0.41 nM. It selectively activates the Gi/o signaling pathway and inhibits cAMP accumulation mediated by 5-HT1AR, without Gs activation and with minimal beta-arrestin recruitment. ST171 reduces hypersensitivity in mouse models of chronic neuropathic and inflammatory pain and is applicable for pain research.
Target:
5-HT Receptor
* VAT and and shipping costs not included. Errors and price changes excepted
