LSD1-IN-44 (Compound 19) is an LSD1 inhibitor with an IC50 of 0.02 µM for the LSD1-CoREST enzyme complex. It exhibits significant antischistosomal activity against newly transformed schistosomula (NTS) and adult Schistosoma mansoni, though its effect on larvae shows some delay. LSD1-IN-44 demonstrates no notable toxicity to human cells and is applicable for schistosomiasis research.
Target-Kategorie:
Histone Demethylase
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