Norquetiapine, CAS [[5747-48-8]] Preis auf Anfrage

Produktübersicht

• Artikelname: Norquetiapine, CAS [[5747-48-8]] Preis auf Anfrage
• Artikelnummer: TGM-T212432
• Hersteller Artikelnummer: T212432
• Alternativnummer: TGM-T212432-10MG,TGM-T212432-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

Norquetiapine (N-Desalkylquetiapine) is a metabolite of Quetiapine and acts as a selective HCN1 channel inhibitor with an IC50 of 13.9 µM. It selectively inhibits norepinephrine reuptake and serves as a partial agonist at the 5-HT1A receptor (Ki = 45 nM). Norquetiapine also functions as an antagonist at presynaptic alpha2 (Ki = 237 nM), 5-HT2C (Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Additionally, it blocks human cardiac sodium channels Nav1.5 in a state-dependent manner. In LPS-injected C57BL/6 mice, Norquetiapine displays partial anti-inflammatory effects. This compound is utilized in research related to depression and inflammation.

Produkteigenschaften

• Molekulargewicht: 295.4
• CAS Nummer: [5747-48-8]
• Formel: C17H17N3S
• Target-Kategorie: 5-HT Receptor

Bilder

T212432