Norquetiapine, CAS [[5747-48-8]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T212432
Supplier Catalog Number:
T212432
Alternative Catalog Number:
TGM-T212432-10MG,TGM-T212432-50MG
Manufacturer:
TargetMol
Category:
Biochemikalien
Norquetiapine (N-Desalkylquetiapine) is a metabolite of Quetiapine and acts as a selective HCN1 channel inhibitor with an IC50 of 13.9 µM. It selectively inhibits norepinephrine reuptake and serves as a partial agonist at the 5-HT1A receptor (Ki = 45 nM). Norquetiapine also functions as an antagonist at presynaptic alpha2 (Ki = 237 nM), 5-HT2C (Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Additionally, it blocks human cardiac sodium channels Nav1.5 in a state-dependent manner. In LPS-injected C57BL/6 mice, Norquetiapine displays partial anti-inflammatory effects. This compound is utilized in research related to depression and inflammation.
Molecular Weight:
295.4
CAS Number:
[5747-48-8]
Formula:
C17H17N3S
Target:
5-HT Receptor
T212432
* VAT and and shipping costs not included. Errors and price changes excepted
