TLR7/8 agonist 13, CAS [[1402802-45-2]] Preis auf Anfrage

Produktübersicht

• Artikelname: TLR7/8 agonist 13, CAS [[1402802-45-2]] Preis auf Anfrage
• Artikelnummer: TGM-T212528
• Hersteller Artikelnummer: T212528
• Alternativnummer: TGM-T212528-10MG,TGM-T212528-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (with a lowest effective concentration (LEC) [hTLR7] of 1.6 µM) and TLR8 (LEC [hTLR8] of 1.6 µM). It acts on human peripheral blood mononuclear cells (hPBMC) with agonistic activity (LEC [hPBMC] = 0.5 µM). In mice and cynomolgus monkeys, TLR7/8 agonist 13 induces endogenous IFNalpha, activates myeloid dendritic cells and monocytes, promoting their differentiation towards a TH1 phenotype. In chronic AAV-HBV mouse models, it reduces viral load and HBV surface antigen levels. TLR7/8 agonist 13 has the potential to indirectly induce IFNgamma, facilitating the response of HBV antigen-specific CD8 T cells. This compound is useful for hepatitis B virus research.

Produkteigenschaften

• Molekulargewicht: 254.33
• CAS Nummer: [1402802-45-2]
• Formel: C12H22N4O2
• Target-Kategorie: Interleukin|||TLR|||HBV|||IFNAR

Bilder

T212528