TLR7/8 agonist 13, CAS [[1402802-45-2]] Preis auf Anfrage

Product Overview

• Article Name: TLR7/8 agonist 13, CAS [[1402802-45-2]] Preis auf Anfrage
• Biozol Catalog Number: TGM-T212528
• Supplier Catalog Number: T212528
• Alternative Catalog Number: TGM-T212528-10MG,TGM-T212528-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (with a lowest effective concentration (LEC) [hTLR7] of 1.6 µM) and TLR8 (LEC [hTLR8] of 1.6 µM). It acts on human peripheral blood mononuclear cells (hPBMC) with agonistic activity (LEC [hPBMC] = 0.5 µM). In mice and cynomolgus monkeys, TLR7/8 agonist 13 induces endogenous IFNalpha, activates myeloid dendritic cells and monocytes, promoting their differentiation towards a TH1 phenotype. In chronic AAV-HBV mouse models, it reduces viral load and HBV surface antigen levels. TLR7/8 agonist 13 has the potential to indirectly induce IFNgamma, facilitating the response of HBV antigen-specific CD8 T cells. This compound is useful for hepatitis B virus research.

Product Properties

• Molecular Weight: 254.33
• CAS Number: [1402802-45-2]
• Formula: C12H22N4O2
• Target: Interleukin|||TLR|||HBV|||IFNAR

Images

T212528