PROTAC FLT3/JAK2/BRD4 Degrader-1, CAS [[3067695-20-6]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC FLT3/JAK2/BRD4 Degrader-1, CAS [[3067695-20-6]] Preis auf Anfrage
• Artikelnummer: TGM-T212552
• Hersteller Artikelnummer: T212552
• Alternativnummer: TGM-T212552-10MG,TGM-T212552-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

PROTACFLT3/JAK2/BRD4 Degrader-1 is a PROTAC degrader targeting FLT3, JAK2, and BRD4, with DC50 values of 5.23 nM, 0.678 nM, and 1.17 nM, respectively. It exhibits potent antiproliferative activity against MV4,11 cells (IC50= 0.79 nM) and FLT3-mutated Ba/F3 cells. Additionally, PROTACFLT3/JAK2/BRD4 Degrader-1 induces apoptosis in MV4,11 cells and demonstrates significant antitumor efficacy in an MV4,11 xenograft model established in NOD SCID mice. This compound is applicable for research in acute myeloid leukemia (AML).

Produkteigenschaften

• Molekulargewicht: 883
• CAS Nummer: [3067695-20-6]
• Formel: C44H51FN10O7S
• Target-Kategorie: FLT|||PROTACs|||Epigenetic Reader Domain|||JAK

Bilder

T212552