PROTAC FLT3/JAK2/BRD4 Degrader-1, CAS [[3067695-20-6]] Preis auf Anfrage

Product Overview

• Article Name: PROTAC FLT3/JAK2/BRD4 Degrader-1, CAS [[3067695-20-6]] Preis auf Anfrage
• Biozol Catalog Number: TGM-T212552
• Supplier Catalog Number: T212552
• Alternative Catalog Number: TGM-T212552-10MG,TGM-T212552-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

PROTACFLT3/JAK2/BRD4 Degrader-1 is a PROTAC degrader targeting FLT3, JAK2, and BRD4, with DC50 values of 5.23 nM, 0.678 nM, and 1.17 nM, respectively. It exhibits potent antiproliferative activity against MV4,11 cells (IC50= 0.79 nM) and FLT3-mutated Ba/F3 cells. Additionally, PROTACFLT3/JAK2/BRD4 Degrader-1 induces apoptosis in MV4,11 cells and demonstrates significant antitumor efficacy in an MV4,11 xenograft model established in NOD SCID mice. This compound is applicable for research in acute myeloid leukemia (AML).

Product Properties

• Molecular Weight: 883
• CAS Number: [3067695-20-6]
• Formula: C44H51FN10O7S
• Target: FLT|||PROTACs|||Epigenetic Reader Domain|||JAK

Images

T212552