SB 203186 is an exceptionally potent and highly selective indole-based 5-HT4 receptor antagonist (Ki = 0.2 nM). It completely blocks 5-HT4-mediated depolarization and cholinergic signal amplification in both central and peripheral neurons at picomolar levels, widely used to investigate the pathogenesis of gastrointestinal smooth muscle motility disorders and arrhythmias.
Molekulargewicht:
272.34
Reinheit:
98.25%
CAS Nummer:
[135938-17-9]
Formel:
C16H20N2O2
Target-Kategorie:
5-HT Receptor
T212733
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