SB 203186 is an exceptionally potent and highly selective indole-based 5-HT4 receptor antagonist (Ki = 0.2 nM). It completely blocks 5-HT4-mediated depolarization and cholinergic signal amplification in both central and peripheral neurons at picomolar levels, widely used to investigate the pathogenesis of gastrointestinal smooth muscle motility disorders and arrhythmias.
Molecular Weight:
272.34
Purity:
98.25%
CAS Number:
[135938-17-9]
Formula:
C16H20N2O2
Target:
5-HT Receptor
T212733
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