NEO-811 is a potent, selective, and cereblon (CRBN)-dependent E3 ubiquitin ligase-mediated proteolytic inhibitor that targets ARNT (HIF-1beta). NEO-811 blocks the ccRCC signaling pathway by degrading ARNT, thereby inhibiting the survival and proliferation of tumor cells. NEO-811 is suitable for use in studies of clear cell renal cell carcinoma (ccRCC).
Molekulargewicht:
543.59
CAS Nummer:
[3084635-77-5]
Formel:
C30H30FN5O4
Target-Kategorie:
HIF/HIF Prolyl-Hydroxylase|||Molecular Glues
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