p-nitro-Pifithrin-alpha is a cell-permeable analog of pifithrin-alpha, a potent p53 inhibitor. It suppresses p53-mediated TGF-beta1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-alpha attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].
Molekulargewicht:
398.27
CAS Nummer:
[389850-21-9]
Formel:
C15H16BrN3O3S
Target-Kategorie:
TGF-beta/Smad|||Others|||Caspase|||MDM-2/p53
T21978
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