Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerization (IC50: 1.2 µM). Besides that, it potently inhibits vincristine binding to tubulin (Ki: 1.4 µM in a non-competitive manner). Dolastatin 10 also shows a moderate effect on enhancing the binding of colchicines to tubulin. In addition, Dolastatin 10 has the inhibitory activity in tubulin-dependent GTP binding.
Molekulargewicht:
899.11
Formel:
C44H69F3N6O8S
Target-Kategorie:
Others
T22631
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