Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerization (IC50: 1.2 µM). Besides that, it potently inhibits vincristine binding to tubulin (Ki: 1.4 µM in a non-competitive manner). Dolastatin 10 also shows a moderate effect on enhancing the binding of colchicines to tubulin. In addition, Dolastatin 10 has the inhibitory activity in tubulin-dependent GTP binding.
Molecular Weight:
899.11
Formula:
C44H69F3N6O8S
Target:
Others
T22631
* VAT and and shipping costs not included. Errors and price changes excepted
