FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=-6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptors conformation and inhibits the WNT/beta-catenin signaling pathway.
Molekulargewicht:
360.43
Reinheit:
99.89%
CAS Nummer:
[1680196-54-6]
Formel:
C21H16N2O2S
Target-Kategorie:
Wnt/beta-catenin
T24076
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