GS143 is a selective IkappaBalpha ubiquitination inhibitor with an IC50 of 5.2 µM for SCFbetaTrCP1-mediated IkappaBalpha ubiquitylation. It suppresses NF-kappaB activation and transcription of target genes without inhibiting proteasome activity. GS143 has anti-asthm[atic] properties.
Molekulargewicht:
466.46
Reinheit:
99.72%
CAS Nummer:
[916232-21-8]
Formel:
C28H19FN2O4
Target-Kategorie:
IkappaB/IKK|||E1/E2/E3 Enzyme|||NF-kappaB
T25465
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten