GS143 is a selective IkappaBalpha ubiquitination inhibitor with an IC50 of 5.2 µM for SCFbetaTrCP1-mediated IkappaBalpha ubiquitylation. It suppresses NF-kappaB activation and transcription of target genes without inhibiting proteasome activity. GS143 has anti-asthm[atic] properties.
Molecular Weight:
466.46
Purity:
99.72%
CAS Number:
[916232-21-8]
Formula:
C28H19FN2O4
Target:
IkappaB/IKK|||E1/E2/E3 Enzyme|||NF-kappaB
T25465
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