AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a p53-dependent apoptosis following compound withdrawal and arrest release.
Molekulargewicht:
344.84
Reinheit:
99.75%
CAS Nummer:
[314022-97-4]
Formel:
C19H21ClN2O2
Target-Kategorie:
Apoptosis|||Microtubule Associated
T26585
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