AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a p53-dependent apoptosis following compound withdrawal and arrest release.
Molecular Weight:
344.84
Purity:
99.75%
CAS Number:
[314022-97-4]
Formula:
C19H21ClN2O2
Target:
Apoptosis|||Microtubule Associated
T26585
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