GNE-140, CAS [[1809794-70-4]]

Produktübersicht

• Artikelname: GNE-140, CAS [[1809794-70-4]]
• Artikelnummer: TGM-T27421
• Hersteller Artikelnummer: T27421
• Alternativnummer: TGM-T27421-1MG,TGM-T27421-5MG,TGM-T27421-10MG,TGM-T27421-25MG,TGM-T27421-50MG,TGM-T27421-100MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: GNE140 , GNE 140

Produktbeschreibung

GNE-140 is a novel and potent lactate dehydrogenase A (LDHA) inhibitor that disrupts glycolytic metabolism in MIA PaCa-2 human pancreatic cancer cells, inducing rapid metabolic reprogramming prior to delayed cell death, with intrinsic resistance observed in OXPHOS-dependent pancreatic cell lines that can be reversed by phenformin, while acquired resistance is driven by AMPK-mTOR-S6K pathway activation, highlighting its value for studying metabolic plasticity and therapeutic resistance.

Produkteigenschaften

• Molekulargewicht: 499.04
• Reinheit: 98.43%
• CAS Nummer: [1809794-70-4]
• Formel: C25H23ClN2O3S2
• Target-Kategorie: Dehydrogenase

Bilder

T27421

T27421