GNE-140, CAS [[1809794-70-4]]

Product Overview

• Article Name: GNE-140, CAS [[1809794-70-4]]
• Biozol Catalog Number: TGM-T27421
• Supplier Catalog Number: T27421
• Alternative Catalog Number: TGM-T27421-1MG,TGM-T27421-5MG,TGM-T27421-10MG,TGM-T27421-25MG,TGM-T27421-50MG,TGM-T27421-100MG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: GNE140 , GNE 140

Product Description

GNE-140 is a novel and potent lactate dehydrogenase A (LDHA) inhibitor that disrupts glycolytic metabolism in MIA PaCa-2 human pancreatic cancer cells, inducing rapid metabolic reprogramming prior to delayed cell death, with intrinsic resistance observed in OXPHOS-dependent pancreatic cell lines that can be reversed by phenformin, while acquired resistance is driven by AMPK-mTOR-S6K pathway activation, highlighting its value for studying metabolic plasticity and therapeutic resistance.

Product Properties

• Molecular Weight: 499.04
• Purity: 98.43%
• CAS Number: [1809794-70-4]
• Formula: C25H23ClN2O3S2
• Target: Dehydrogenase

Images

T27421

T27421