UR-7247 is a novel orally active angiotensin II subtype I (AT1) antagonist, demonstrating very long pharmacological effects. in vivo studies indicate no significant difference between 10 mg UR-7247 and 100 mg losartan four hours post-administration, while in vitro blockade with 100 mg losartan exceeds that observed with UR-7247, confirming UR-7247s extended plasma half-life potentially due to high-affinity protein binding, highlighting its long-lasting, well-tolerated AT1 receptor antagonism in healthy subjects.
Molekulargewicht:
430.5
Reinheit:
98.88%
CAS Nummer:
[177847-28-8]
Formel:
C24H26N6O2
Target-Kategorie:
RAAS
T29075
T29075
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