PF-04856264 is a Nav1.7 blocker.Nav1.7 is a chondrocyte modulator and a therapeutic target in osteoarthritis.Inhibition of Nav1.7 modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain and inhibits ERK expression, which has analgesic and anti-inflammatory effects.
Molekulargewicht:
437.5
Reinheit:
97.43%
CAS Nummer:
[1235397-05-3]
Formel:
C20H15N5O3S2
Target-Kategorie:
Sodium Channel
T33943
T33943
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