PF-5274857 hydrochloride is a potent, orally active, selective Smo antagonist (IC50=5.8 nM, Ki=4.6 nM) that is permeable through the blood-brain barrier. It has research potential in various tumors, including brain tumors and brain metastases driven by activated Hh pathways.
Molekulargewicht:
473.42
CAS Nummer:
[1613439-62-5]
Formel:
C20H26Cl2N4O3S
Target-Kategorie:
Others|||Smo
T35563
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