Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinsons disease (PD) patients (IC50 = 7.8 µM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.
Molekulargewicht:
425.85
CAS Nummer:
[2624336-91-8]
Formel:
C20H17FN7OCl
Target-Kategorie:
Others
T35670
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