Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinsons disease (PD) patients (IC50 = 7.8 µM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.
Molecular Weight:
425.85
CAS Number:
[2624336-91-8]
Formula:
C20H17FN7OCl
Target:
Others
T35670
* VAT and and shipping costs not included. Errors and price changes excepted
