TNF-alpha antagonist is an exocyclic peptide that mimics the critical TNF-alpha recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-kappaB (RANK) and TNF-alphas recruitment and activation of osteoclasts. TNF-alpha antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.
Molekulargewicht:
1226.39
CAS Nummer:
[199999-60-5]
Formel:
C58H71N11O15S2
Target-Kategorie:
TNF
T36127
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
