TNF-alpha antagonist is an exocyclic peptide that mimics the critical TNF-alpha recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-kappaB (RANK) and TNF-alphas recruitment and activation of osteoclasts. TNF-alpha antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.
Molecular Weight:
1226.39
CAS Number:
[199999-60-5]
Formula:
C58H71N11O15S2
Target:
TNF
T36127
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