Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 µM), to destabilize microtubules and disrupt mitosis. At 50 µM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization.
Molekulargewicht:
386.51
CAS Nummer:
[361431-33-6]
Formel:
C19H26N6OS
Target-Kategorie:
Others|||Microtubule Associated
T36358
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