Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 µM), to destabilize microtubules and disrupt mitosis. At 50 µM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization.
Molecular Weight:
386.51
CAS Number:
[361431-33-6]
Formula:
C19H26N6OS
Target:
Others|||Microtubule Associated
T36358
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