2H-Cho-Arg (trifluoroacetate salt), CAS [[1609010-59-4]]

Produktübersicht

• Artikelname: 2H-Cho-Arg (trifluoroacetate salt), CAS [[1609010-59-4]]
• Artikelnummer: TGM-T36368
• Hersteller Artikelnummer: T36368
• Alternativnummer: TGM-T36368-1MG,TGM-T36368-5MG,TGM-T36368-10MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-beta-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein , but not by inhibitors of clathrin- or micropinocytosis-mediated endocytosis. It induces cytotoxicity in H1299 cells (IC50 = 92.7 µg/ml).

Produkteigenschaften

• Molekulargewicht: 886.06
• CAS Nummer: [1609010-59-4]
• Formel: C43H73F6N5O7
• Target-Kategorie: Others|||Liposome

Bilder

T36368