2H-Cho-Arg (trifluoroacetate salt), CAS [[1609010-59-4]]

Product Overview

• Article Name: 2H-Cho-Arg (trifluoroacetate salt), CAS [[1609010-59-4]]
• Biozol Catalog Number: TGM-T36368
• Supplier Catalog Number: T36368
• Alternative Catalog Number: TGM-T36368-1MG,TGM-T36368-5MG,TGM-T36368-10MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-beta-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein , but not by inhibitors of clathrin- or micropinocytosis-mediated endocytosis. It induces cytotoxicity in H1299 cells (IC50 = 92.7 µg/ml).

Product Properties

• Molecular Weight: 886.06
• CAS Number: [1609010-59-4]
• Formula: C43H73F6N5O7
• Target: Others|||Liposome

Images

T36368