CMLD-2, CAS [[958843-91-9]]

Produktübersicht

• Artikelname: CMLD-2, CAS [[958843-91-9]]
• Artikelnummer: TGM-T36493
• Hersteller Artikelnummer: T36493
• Alternativnummer: TGM-T36493-1MLX10MM(INDMSO),TGM-T36493-1MG,TGM-T36493-5MG,TGM-T36493-10MG,TGM-T36493-25MG,TGM-T36493-50MG,TGM-T36493-100MG,TGM-T36493-500MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor effects through MAD2 downregulation. CMLD-2 (1-75 µM , 24-72 h) had an inhibitory effect on the viability of thyroid cancer cells.CMLD-2 (20-30 µM , 24-48 h) activated caspases and induced apoptosis in H1299 and A549 cells.CMLD-2 (30 µM , 24-48 h) induced G1 cell cycle arrest in H1299 and A549 cells and mitochondrial perturbation. CMLD-2 (30 µM , 24-48 h) reduced the expression of HuR and HuR-regulated mRNAs and proteins in H1299 cells.CMLD-2 (35 µM , 72 h) decreased the directional migration ability of SW1736, 8505C, BCPAP and K1 cells.CMLD-2 induced the migration of SW1736, 8505C, BCPAP and K1 cells with a strong decrease in MAD2 mRNA levels.

Produkteigenschaften

• Molekulargewicht: 513.58
• Reinheit: 99.16%
• CAS Nummer: [958843-91-9]
• Formel: C31H31NO6
• Target-Kategorie: Apoptosis|||HuR

Bilder

T36493